Understanding Conduction System Development
نویسندگان
چکیده
منابع مشابه
Understanding conduction system development: a hop, skip and jump away?
In the late 1800s, W.H. Gaskell demonstrated that impulse propagation from the atrium to the ventricle of the tortoise heart reflected conduction along myocardial tissue rather than nerve tissue.1 A decade later, Stanley Kent proposed, incorrectly as it turns out, that multiple muscular connections normally link the atria and ventricles of mammals,2 but it was not until the remarkably detailed ...
متن کاملDevelopment of the cardiac conduction system
The heterogeneous tissues of the cardiac pacemaking and conduction system are responsible for setting, maintaining and coordinating the rhythmic pumping of the heart (reviewed Thompson et al., 1995; Moorman et al., 1998; Gourdie et al., 1999). Anomalous development of this specialized network has been implicated in pediatric arrhythmia and other congenital abnormalities of cardiac activation (S...
متن کاملDevelopment of the cardiac conduction system.
The cardiac conduction system (CCS) is a specialized tissue network that initiates and maintains a rhythmic heartbeat. The CCS consists of several functional subcomponents responsible for producing a pacemaking impulse and distributing action potentials across the heart in a coordinated manner. The formation of the distinct subcomponents of the CCS occurs within a precise temporal and spatial f...
متن کاملGene regulatory networks in cardiac conduction system development.
The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Given its critical role in coordinating cardiac performance, a detailed analysis of the molecular mechanisms underlying conduction system formation should inform our understanding of arrhythmia pathophysiology and affect the development of novel therapeutic strategies. His...
متن کاملBiphasic development of the mammalian ventricular conduction system.
RATIONALE The ventricular conduction system controls the propagation of electric activity through the heart to coordinate cardiac contraction. This system is composed of specialized cardiomyocytes organized in defined structures including central components and a peripheral Purkinje fiber network. How the mammalian ventricular conduction system is established during development remains controve...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 2005
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000165653.83279.20